Monosodium glutamate no longer GRAS?

On November 15, 2011, Truth in Labeling co-founder Jack Samuels suffered a massive heart attack. He died on January 15, 2012 from heart damage exacerbated by complications caused by MSG — MSG in the electrode tabs applied to his skin; MSG in the dextrose solution used to deliver the drugs that would crystallize in the non-MSG Ringer’s solution and MSG in the starch and cornstarch components of the medications given to him when the IVs were withdrawn.

Jack Samuels

Had the FDA not lied about the toxic potential of MSG, had the medical community not believed them, had the MSG in the solutions and meds been identified on product inserts, Jack might be alive today. Had Jack not spent half of the last quarter of his life fibrillating following ingestion of MSG hidden in food, he might not have had the heart attack in the first place.

On January 4, 2021, I filed a Citizen Petition requesting that the FDA discontinue representing the interests of those who manufacture monosodium glutamate (MSG) – that the public be told the truth about the toxicity of MSG and its excitotoxic, brain damaging L-glutamic acid. FDA Commissioner Stephen M. Hahn, M.D. has been asked to revoke the GRAS (generally recognized as safe) status of MSG and L-glutamic acid for any use in human food.

Copies of the Petition from the FDA are available here. (To read or comment, simply insert the petition docket number FDA-2021-P-0035 in the space provided and use the “comment now” button). The petition and related material are also available at the webpage of the Truth in Labeling Campaign.

The petition contains a Statement of Grounds providing evidence of the need for revoking the GRAS status of MSG and L-glutamic acid for use in human food.

Details pertaining to the toxic effects of MSG, FDA/industry liaison, industry protocols used for production of negative results, and suppression of information can be accessed at these respective links.

If you have questions or comments other than those for the FDA please email me at

But of greatest importance, please tell the FDA that MSG should be stripped of its GRAS status, and search out others to do the same, by commenting to the FDA on the Citizen Petition:

Thank you for caring.

Adrienne Samuels

If you have questions or comments, we’d love to hear from you.  And if you have hints for others on how to avoid exposure to MfG, send them along, too, we’ll put them up on Facebook.  You can also reach us at and follow us on Twitter @truthlabeling

A snake in the GRAS

When you hear that the FDA considers monosodium glutamate GRAS – or, generally recognized as safe – what does that mean? It’s certainly one of the “selling points” that industry likes to toss around a lot as evidence that monosodium glutamate is harmless.

But that GRAS designation is inherently deceiving.

Sixty-one years ago, following passage of the Food Additives Amendment of 1958, the FDA grandfathered monosodium glutamate into a category of additives called GRAS. There was no testing done or even reviewed by the FDA to determine if monosodium glutamate was indeed safe. The GRAS classification was solely based on monosodium glutamate having been in use without objection prior to 1958. The actual safety of pre-1958 monosodium glutamate was not then, and never has been, established.

But to make using a GRAS label for monosodium glutamate even more farfetched, is the fact that the monosodium glutamate in use in the U.S. today is not even the same as the monosodium glutamate that was grandfathered as GRAS in 1958. From 1920 until 1956, the process underlying production of glutamic acid and monosodium glutamate in Japan had been one of extraction, a slow and costly method (1). Then, around 1956, Ajinomoto Co., Inc. succeeded in producing glutamic acid and monosodium glutamate using genetically modified bacteria to secrete the glutamic acid used in monosodium glutamate through their cell walls, and cost saving, large-scale production of glutamic acid and monosodium glutamate through fermentation began (2,3).

Approximately 10 years later, the first published report of an adverse reaction to monosodium glutamate appeared in the New England Journal of Medicine (4), and a study demonstrating that monosodium glutamate was excitotoxic, causing brain damage, endocrine disorders and behavior disorders, was published in the journal Science in 1969 (5). Of interest to note is the fact that by the time 10 years had gone by, grocery shelves were overflowing with processed foods loaded with monosodium glutamate, hydrolyzed protein products, autolyzed yeasts and lots of other ingredients that contained the same toxic free glutamic acid found in monosodium glutamate.

If you have questions or comments, we’d love to hear from you. If you have hints for others on how to avoid exposure to MfG, send them along, too, and we’ll put them up on Facebook. Or you can reach us at and follow us on Twitter @truthlabeling.


  1. Van Nostrand’s Scientific Encyclopedia. 6th ed. New York: Van Nostrand Reinhold, 1983:1211-2.
  2. Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed. Vol 2. New York: Wiley, 1978:410-21.
  3. Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. New York: Wiley, 1992:571-9.
  4. Kwok RHM. The Chinese restaurant syndrome. Letter to the editor. N Engl J Med. 1968;278(14):796.
  5. Olney JW. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 1969;164:719-721.