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EVIDENCE OF MSG-induced HUMAN ADVERSE REACTIONS:

THE HUMAN STUDIES
(Compiled by Adrienne Samuels, Ph.D., July, 2010)

Evidence of monosodium glutamate-induced adverse reactions comes from epidemiological studies that demonstrate that monosodium glutamate causes adverse reactions in humans(1-4); from studies and case reports published by concerned physicians(1, 5-41); and from reports of consumers who find their symptoms abate after discontinuing use of products that contain monosodium glutamate, but reoccur when monosodium glutamate is ingested.

The epidemiological studies done in the United States in the 1970s suggest that 25% to 30% of the population was intolerant of monosodium glutamate at levels then found in food. Considering the expanded use of monosodium glutamate and other MSG-containing food additives since that time, we conservatively estimate that approximately 40% of the U.S. population presently react adversely to MSG.

The Truth in Labeling Campaign (TLC)(44) receives letters daily from consumers who find that their adverse reactions abate when they eliminate monosodium glutamate from their food, drugs, and dietary supplements.  A number of these letters have been reproduced on the TLC web page.  See Consumers Tell Us That….

Ironically, industry-sponsored studies themselves provide examples of adverse reactions following ingestion of monosodium glutamate in monosodium glutamate test material(45-61).  In discussing the flaws in industry-sponsored studies elsewhere, we have pointed to the fact that although each study is designed to minimize the number of reactions to monosodium glutamate test material, a number of reactions do occur; but if noted at all, any report of such reactions is most often tucked away in a table, while discussion in the body of the article and in the discussion section focuses on the fact that there were as many reactions to placebos as there were to monosodium glutamate test material.  (See “Evidence of monosodium glutamate-induced adverse reactions_double-blind studies”.)  Finally, it must be noted that one of the reasons that placebo responses roughly approximate the number of reactions to monosodium glutamate in industry-sponsored studies is the fact that in all of the double-blind studies referenced here, the placebos were laced with aspartame (which contains neurotoxic aspartic acid, a structural analog of the glutamic acid found in monosodium glutamate).

Although reports of adverse reactions are growing, there seems to be no incentive to publish case studies or case reports in the medical literature. No one compensates physicians for writing up case studies, and the FDA has collected, but never solicited, reports of adverse reactions to monosodium glutamate or other MSG-containing ingredients. There are studies that warn of hazards of MSG-ingestion, but they are studies of pathophysiology related to glutamate, not studies of adverse reactions per se.  The one exception may be the work of He et al. who found that weight gain and obesity are related to ingestion of monosodium glutamate(62).

The adverse reactions noted (and summarily dismissed) in industry-sponsored studies of the safety of monosodium glutamate themselves present compelling evidence of the toxic potential of monosodium glutamate.

 

 

REFERENCES

1. Schaumburg HH, Byck R, Gerstl R, Mashman JH. Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome. Science. 1969;163(869):826-828.

2. Reif-Lehrer LA. Questionnaire study of the prevalence of chinese restaurant syndrome. Fed Proc. 1977;36(5):1617-1623.

3. Kenney RA, Tidball CS. Human susceptibility to oral monosodium L-glutamate. Am J Clin Nutr. 1972;25(2):140-146.

4. Kerr GR, Wu-Lee M, El-Lozy M, McGandy R, Stare F. Food-symptomatology questionnaires: risks of demand-bias questions and population-biased surveys. In: Filer LJ Jr, Garattini S, Kare MR, Reynolds WA, Wurtman RJ, eds. Glutamic Acid: Advances in Biochemistry and Physiology. New York: Raven Press; 1979:375-387.

5. Kwok RHM. The Chinese restaurant syndrome. N Engl J Med. 1968;278(14):796.

6. Schaumburg H. Chinese-restaurant Syndrome. N Engl J Med. 1968;278(20):1122.

7. McCaghren TJ. Chinese-restaurant syndrome. N Engl J Med. 1968;278(20):1123.

8. Menken M. Chinese-restaurant syndrome. N Engl J Med. 1968;278(20):1123.

9. Migden W. Chinese-restaurant syndrome. N Engl J Med. 1968;278(20):1123.

10. Rath J. Chinese-restaurant syndrome. N Engl J Med. 1968;278(20):1123.

11. Beron EL. Chinese-restaurant syndrome. N Engl J Med. 1968;278(20):1123.

12. Kandall SR. Chinese-restaurant syndrome. N Engl J Med. 1968;278(20):1123.

13. Gordon ME. Chinese-restaurant syndrome. N Engl J Med. 1968;278(20):1123-1124.

14. Schaumburg HH, Byck R. Sin cib-syn: accent on glutamate. N Engl J Med. 1968;279(2):105.

15. Ambos M, Leavitt NR, Marmorek L, Wolschina SB. Sin cib-syn: accent on glutamate. N Engl J Med. 1968;279(2):105.

16. Upton ARM, Barrows HS. Chinese-restaurant syndrome recurrence. N Engl J Med. 1972;286(16):893-894.

17. Ghadimi H, Kumar S, Abaci F. Studies on monosodium glutamate ingestion: 1. biochemical explanation of Chinese Restaurant Syndrome. Biochemical Medicine. 1971;5(5):447-456.

18. Gann D. Ventricular tachycardia in a patient with the "Chinese restaurant syndrome." South Med J. 1977;70(7):879-880.

19. Asnes RS. Chinese restaurant syndrome in an infant. Clin Pediat. 1980;19(10):705-706.

20. Cochran JW, Cochran AH. Monosodium glutamania: the Chinese restaurant syndrome revisited. JAMA. 1984;252(7):899.

21. Freed DLJ, Carter R. Neuropathy due to monosodium glutamate intolerance. Ann Allergy. 1982;48(2):96-97.

22. Ratner D, Esmel E, Shoshani E. Adverse effects of monosodium glutamate: a diagnostic problem. Israel J Med Sci. 1984;20(3):252-253.

23. Botey J, Cozzo M, Marin A, Eseverri JL. Monosodium glutamate and skin pathology in pediatric allergology.  Allergol Immunopathol (Madr). 1988 Nov-Dec;16(6):425-8.

24. Squire EN Jr. Angio-oedema and monosodium glutamate. Lancet. 1987;1(8539):988.

25  Pohl R, Balon R, Berchou R. Reaction to chicken nuggets in a patient taking an MAOI. Am J Psychiatry. 1988;145(5):651.

26. Colman AD. Possible psychiatric reactions to monosodium glutamate. N Engl J Med. 1978;299(16):902.

27.  Alston RM. Chinese-restaurant syndrome. N Engl J Med. 1976;294(4):225.

28. Reif-Lehrer L, Stemmermann MB. Letter: Monosodium glutamate intolerance in children. N Engl J Med. 1975;293(23):1204-1205.

29. Andermann F, Vanasse M, Wolfe LS. Correspondence: Shuddering attacks in children: essential tremor and monosodium glutamate. N Engl J Med. 1975;295(3):174.

30. Reif-Lehrer L. Letter: A search for children with possible MSG intolerance. Pediatrics. 1976;58(5):771-772.

31. Reif-Lehrer L. Possible significance of adverse reactions to glutamate in humans. Fed Proc. 1976;35(11):2205-2211.

32. Neumann HH. Soup? It may be hazardous to your health. Am Heart J. 1976;92(2):266.

33. Allen DJ, Baker GJ. Chinese-restaurant asthma. N Engl J Med. 1981;305(19):1154-1155.

34. Allen DH, Delohery J, Baker GJ. Monosodium L-glutamate-induced asthma. J Allergy Clin Immunol. 1987;80(4):530-537.

35. Moneret-Vautrin DA. Monosodium glutamate-induced asthma: Study of the potential risk in 30 asthmatics and review of the literature. Allergic et Immunologie. 1987;19(1):29-35.

36. Sweatman MC, Tasker R, Warner JO, Ferguson MM, Mitchell DN.  Oro-facial granulomatosis. Response to elemental diet and provocation by food additives.  Clin Allergy. 1986;16(4):331-338.

37. Oliver AJ, Rich AM, Reade PC, Varigos GA, Radden BG.  Monosodium glutamate-related orofacial granulomatosis. Oral Surg Oral Med Oral Patho. 1991;71(5):560-564.

38. Smith JD, Terpening CM, Schmidt SO, Gums JG. Relief of fibromyalgia symptoms following discontinuation of dietary excitotoxins.  Ann Pharmacothe. 2001;35(6):702-706.

39. Collison KS, Maqbool Z, Saleh SM, et al. Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease.  J Lipid Res. 2009 Aug;50(8):1521-37. Epub 2008 Nov 11. doi:10.1194/jlr.M800418-JLR200

40. Nakanishi Y, Tsuneyama K, Fujimoto M, et al.  Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia. J Autoimmun. 2008;30(1-2):42-50.

41 Hermanussen M, Tresguerres JAF.  How much glutamate is toxic in paediatric parenteral nutrition?  Acta Padeiatrica. 2005;94(11);16-19.

42. Kiss P, Hauser D, Tamas A, et al. Changes in open-field activity and novelty-seeking behavior in periadolescent rats neonatally treated with monosodium glutamate. Neurotox Res. 2007;12(2):85-93.

43. Ali MM, Bawari M, Misra UK, Babu GN.  Locomotor and learning deficits in adult rats exposed to monosodium-L-glutamate during early life. Neurosci Lett.  2000;284(1-2):57-60.

44. Truth in Labeling Campaign.  www.truthinlabeling.org. Accessed February 9, 2009.

45. Altman DR, Fitzgerald T, Chiaramonte LT. Double blind placebo controlled challenge (DBPCC) of persons reporting adverse reactions to monosodium glutamate (MSG). J Allergy Clin Immunol. 1994;93(1 Pt 2):303 (Abstract 844).

46. Geha RS, Beiser A, Ren C, et al. Multicenter multiphase double blind placebo controlled study to evaluate alleged reactions to monosodium glutamate (MSG). J Allergy Clin Immunol. 2000;106(5):973-980.

47. Germano P, Cohen SG, Hahn B, Metcalfe DD. An evaluation of clinical reactions to monosodium glutamate (MSG) in asthmatics using a blinded, placebo controlled challenge. J Allergy Clin Immunol. 1991;87(1 Pt 2):177 (Abstract 155).

48. Germano P, Cohen SG, Hibbard V, Metcalfe DD. Assessment of bronchial hyperactivity by methacholine challenge (MTC) in asthmatics before and after monosodium glutamate (MSG) administration. J Allergy Clin Immunol. 1993;91(1 Pt 2):340 (Abstract 798).

49. Kenney RA. Placebo controlled studies of human reaction to oral monosodium L glutamate. In Filer LJ Jr, Garattini S, Kare MR, Reynolds WA, Wurtman RJ, eds. Glutamic acid: advances in biochemistry and physiology. New York: Raven; 1979:363-373.

50. Kerr GR, Wu Lee M, El Lozy M, McGandy R, Stare FJ. Prevalence of the "Chinese restaurant syndrome." J Am Diet Assoc. 1979;75(1):29 33.

51. Morselli P, Garattini S. Monosodium glutamate and the Chinese restaurant syndrome. Nature. 1970;227(5258):611 612.

52. Kenney RA. The Chinese restaurant syndrome: an anecdote revisited.  Food Chem Toxicol. 1986;24(4):351-354.

53. Prawirohardjono W, Dwiprahasto I, Astuti I, et al. The administration to Indonesians of monosodium L-glutamate in Indonesian foods; an assessment of adverse reactions in a randomized double-blind, crossover, placebo-controlled study. J Nutr. 2000;130(4S Suppl):1074S-6S.

54. Rosenblum L, Bradley J, Coulston F. Single and double blind studies with oral monosodium glutamate in man. Toxicol Appl Pharmacol. 1971;18(2):367-373.

55. Tanphaichitr V, Srianujata S, Pothisiri P, Sammasut R,  Kulapongese S. Postprandial responses to Thai foods with and without added monosodium L-glutamate.  Nutr Rep Int. 1983;28(4):783-792.

56. Tarasoff L, Kelly MF. Monosodium L glutamate: a double blind study and review. Food Chem Toxic. 1993;31(12):1019 1035.

57. Wilkin JK. Does monosodium glutamate cause flushing (or merely Aglutamania@)? J Am Acad Dermatol. 1986;15(2 Pt 1):225-230.

58. Woessner KM,  Simon RA, Stevenson DD. Monosodium glutamate sensitivity in asthma. J Allergy Clin Immunol. 1999;104(2 Pt 1):305-310.

59.  Zanda G, Franciosi P, Tognoin G, et al.  A double blind study on the effects of monosodium glutamate in man.  Biomedicine. 1973;19(5):202-204.

60. Yang WH, Drouin MA, Herbert M, Mao Y. The monosodium glutamate symptom complex: assessment in a double blind, placebo controlled, randomized study. J Allergy Clin Immunol. 1997;99(6 Pt 1):757 762.

61. Tanphaichitr V, Srianujata S, Leelahabul P,  Kulapongse S, Patchimasiri S, Pothisiri P. Effect of monosodium L-glutamate in take on protein-calorie status in healthy Thai adults. Nutr Rep Int. 1985;32(5):1073-1080.

62. He K, Zhao L, Daviglus ML, et al. Association of Monosodium Glutamate Intake With Overweight in Chinese Adults: The INTERMAP Study. Obesity. 2008; 16(8): 1875-1880. Epub 2008 May 22. 

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