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MSG and the Glutamate Cascade   

The medical literature is replete with studies of addiction, stroke, epilepsy, degenerative disorders (Alzheimer's disease, Parkinson's disease, and ALS, for example), brain trauma, neuropathic pain, schizophrenia, anxiety, and depression -- seemingly diverse disease processes of the central nervous system related by the fact that glutamate plays a significant role in each.  On October 16, 2010, the National Library of Medicine retrieval system (www.pubmed.gov) listed references to glutamate combined with these various disease states as follows:

Number of Pubmed References to Glutamate and:

Alzheimer’s

Parkinson’s

amyotrophic lateral sclerosis

Brain trauma

Neuropathic pain

Schizophrenia

Anxiety

Depression

1,654 studies

1,308 studies

744 studies

1,038 studies

280 studies

1,731 studies

895 studies

3,275 studies

Reading these studies, the reader will find discussion of damaged or overly sensitive glutamate receptors, and malfunctioning glutamate transport.  The reader will also find discussion of “glutamate pools” where excess glutamate is stored – and then sometimes released to cause brain damage.  Rarely mentioned, however, is the role that ingestion of excess amounts of processed free glutamate (MSG) might play in producing these diseases; and if mentioned at all, it is by researchers outside of the United States.

In May, 1998 a conference was hosted by the National Institutes of Health as a vehicle through which researchers might share what they knew about the relevance of glutamic acid to these various disease processes.   The conference was titled, “The Glutamate Cascade; Common Pathways of Central Nervous System Disease States”1.  In typical FDA, EPA, USDA fashion -- representing the interests of the glutamate industry -- the NIH refused to consider discussing the role of processed free glutamic acid (MSG) found in processed food in causing or exacerbating these disease processes.

REFEENCES

1. National Institutes of Health, The Glutamate Cascade; Common Pathways of Central Nervous System Disease States. Conference. Bethesda, Maryland, May 3-5, 1998.

To access information about the conference go to:

http://archives.drugabuse.gov/meetings/Glutamate/abstracts.html

http://archives.drugabuse.gov/meetings/Glutamate/Index.html and

http://archives.drugabuse.gov/meetings/Glutamate/program.html

 

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This page was last updated on October 27, 2010.